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Pediatric Endocrinology and Growth Award for a study in CEMBIO

11 mayo 2017 1.752 views No Comment

The collaboration between CEMBIO group and the group leaded by Prof. Dr. Jesús Argente from Hospital Niño Jesús (Madrid) has been awarded with the ‘Pediatric Endocrinology and Growth’ award for their work ‘Early onset metabolomic alterations in insulin resistant obese children‘. This study has revealed how three apparently independent processes (central carbon metabolism, inflammation and intestinal microflora) are implicated in the interaction between obesity and insulin resistance (the pre-diabetes stage).

CEMBIO group (May 2017)

CEMBIO group (May 2017)

Through the metabolomic approach we have been able to propose a set of compounds whose determination could be implemented in routine clinical analyzes, to identify individuals with a higher risk of developing complications. This would allow to approach personalized preventive and therapeutic strategies.

This result has special relevance, because at present the possibility of being able to evaluate the insulin resistance before the onset of diabetes shows numerous complications. In addition, in order to detect type 2 diabetes in children, current recommendations emphasize difficulties in distinguishing it (in the early stages) from type 1 diabetes, and in certain patients in whom obesity may also occur.

One of the most striking results has been the finding that there are metabolic differences between the boys and girls who participated in our study. Although it is often estimated that before the hormonal changes associated with puberty the metabolism of both is equivalent, they presented the metabolic alterations related to insulin resistance with greater intensity than they.

In summary, our study offers new insights into the metabolic profile that characterizes two conditions: obesity and insulin resistance; Often associated with the onset of diabetes, but not directly correlated with it (not all obese are diabetic, not all diabetics are obese). This study, therefore, sheds light on the pathophysiological alterations, which may be characteristic of the factors that predispose to future complications.